Key result
Intradermal immunization with a single large dose of poliomyelitis virus produced active immunity without causing abortive or paralytic signs in a series of four Macacus rhesus monkeys.
Why the study?
Does a single large dose of poliomyelitis virus administered intradermally produce active immunity in Macacus rhesus monkeys?
Population
Macacus rhesus monkeys (n=4)
Design
Preclinical
Authors
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Demonstrates safe active immunization against poliomyelitis in rhesus monkeys; leaves open translation to human vaccine strategies.
Does a single large dose of poliomyelitis virus administered intradermally produce active immunity in Macacus rhesus monkeys?
Intradermal administration of a single large dose of poliomyelitis virus successfully induces active immunity in rhesus monkeys without causing disease symptoms.
C. P. Rhoads (1930) studied this question. Intradermal immunization with a single large dose of poliomyelitis virus produced active immunity without causing abortive or paralytic signs in a series of four Macacus rhesus monkeys.
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