Key result
Injections of poliomyelitis virus into the gastrointestinal tract of 71 Macacus rhesus monkeys resulted in quadriplegia and death in 12, fleeting weakness in 7, and obvious paresis or plegia in 51.
Population
71 Macacus rhesus monkeys
Design
Preclinical
Authors
Loading...
Supports GI poliovirus transmission in primate models; leaves open human relevance and modern implications.
Inoculation of poliomyelitis virus into the gastrointestinal tract of Macacus rhesus monkeys results in varying degrees of paralysis and death.
John A. Toomey (1936) studied Poliomyelitis (n=71). Injections of combinations of poliomyelitis virus was evaluated on Development of paralysis or weakness. Injections of poliomyelitis virus into the gastrointestinal tract of 71 Macacus rhesus monkeys resulted in quadriplegia and death in 12, fleeting weakness in 7, and obvious paresis or plegia in 51.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: