The study found no evidence of type C oncornaviruses in lymphoblastoid cell lines from patients with active systemic lupus erythematosus, failing to support the postulated association of oncornavirus infection in human SLE.
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No type C oncornaviruses detected in SLE lymphoblastoid cells; leaves open viral etiology and requires further study.
Lymphoblastoid cell lines were derived from patients with active systemic lupus erythematosus by allowing spontaneous transformation of peripheral B lymphocytes (B cells) harboring endogenous Epstein-Barr virus or by superinfecting peripheral lymphocytes with exogeneous Epstein-Barr virus. Results of extensive studies aimed at identifying type C oncornaviruses in these lymphoblastoid cells were entirely negative by electron microscopy, DNA-DNA hybridization, reverse transcriptase assays, and cocultivation experiments. These results do not support the postulated association of oncornavirus infection in human systemic erythematosus.
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Hicks et al. (1979) studied this question.
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