Key result
Baseline albumin excretion rate (P<0.0001), mean arterial pressure (P=0.02), and HbA1 (P=0.05) were the strongest predictors of progression to persistent microalbuminuria in Type 1 diabetes.
Why the study?
What are the predictors of the development of persistent microalbuminuria in normotensive patients with Type 1 diabetes mellitus?
Population
148 initially normotensive Type 1 diabetic patients with normal albumin excretion (< 30 μg/min)
Design
Cohort
Follow-up
median 7 years (range 6 months to 8 years)
Authors
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May refine risk stratification by baseline albumin excretion rate and HbA1 in normotensive type 1 diabetes; hypothesis-generating, requires prospective validation.
Cohort (n=148)
What are the predictors of the development of persistent microalbuminuria in normotensive patients with Type 1 diabetes mellitus?
p-value: p=<0.0001
Baseline albumin excretion rate, blood pressure, and HbA1 are the strongest predictors of developing persistent microalbuminuria in normotensive patients with Type 1 diabetes.
The Microalbuminuria Collaborative Study Group (1999) conducted a cohort in Type 1 diabetes mellitus (n=148). Baseline albumin excretion rate, blood pressure, and HbA1 vs. Lower baseline levels was evaluated on Progression to persistent microalbuminuria (albumin excretion rate ≥ 30 μg/min on at least two consecutive occasions) (p=<0.0001). Baseline albumin excretion rate (P<0.0001), mean arterial pressure (P=0.02), and HbA1 (P=0.05) were the strongest predictors of progression to persistent microalbuminuria in Type 1 diabetes.
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