Key result
Neither eNOS Glu298Asp (OR 0.958; 95% CI 0.747-1.228) nor ACE insertion-deletion (OR 0.987; 95% CI 0.698-1.395) gene polymorphisms were significantly associated with the risk of pre-eclampsia.
Why the study?
Do eNOS (Glu298Asp) and ACE (intron 16 insertion-deletion) gene polymorphisms increase the risk of pre-eclampsia in women?
Meta-Analysis
Do eNOS (Glu298Asp) and ACE (intron 16 insertion-deletion) gene polymorphisms increase the risk of pre-eclampsia in women?
This meta-analysis found no significant association between eNOS (Glu298Asp) or ACE (intron 16 insertion-deletion) gene polymorphisms and the risk of pre-eclampsia.
Answers are grounded in this paper and cite their sources.
These polymorphisms should not inform pre-eclampsia risk assessment or screening; leaves open identification of other genetic contributors.
A meta-analyses of endothelial nitric oxide synthase (eNOS) and angiotensin-converting enzyme (ACE) gene polymorphisms in pre-eclampsia was performed. We shortlisted 33 studies (17 for ACE; 16 for eNOS gene polymorphisms), of which 29 articles (16 for ACE and 15 for eNOS) were analysed. Overall, 1,620 cases with pre-eclampsia and 2,158 controls were analysed for intron 16 insertion-deletion polymorphism in ACE gene. A total of 1,610 subjects with pre-eclampsia and 2,875 controls were analysed for the Glu298Asp in eNOS gene. Overall, the random-effects odds ratio (OR) with Glu298Asp in eNOS gene was 0.958 (95% confidence intervals, CI 0.747-1.228, p > 0.05), and for the insertion-deletion/ACE polymorphism was 0.987 (95% CI 0.698-1.395, p > 0.05). Significant heterogeneity was observed in the studies that evaluated polymorphisms in ACE (Q value = 55.6; I(2) = 73; p value = 0.000); and eNOS (Q value = 37.2; I(2) = 62.4; p value = 0.001) polymorphisms. No significant risk of pre-eclampsia was observed in both eNOS and ACE genes with these polymorphisms.
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Shaik et al. (2011) conducted a meta-analysis in Pre-eclampsia. eNOS (Glu298Asp) and ACE (intron 16 insertion-deletion) gene polymorphisms vs. Controls (without pre-eclampsia) was evaluated on Risk of pre-eclampsia (OR 0.958, 95% CI 0.747-1.228, p=> 0.05). Neither eNOS Glu298Asp (OR 0.958; 95% CI 0.747-1.228) nor ACE insertion-deletion (OR 0.987; 95% CI 0.698-1.395) gene polymorphisms were significantly associated with the risk of pre-eclampsia.
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