Key result
Carbonyl iron ferromagnetic fine particles introduced into the vascular system require suitable coating, spherical shape, and superposed magnetic fields to aggregate and disperse in small vessels.
Population
Rats, dogs, rabbits, and in vitro human blood
Design
Preclinical
Authors
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Should not change practice; hypothesis-generating for magnetic vascular targeting, requiring human trials before clinical consideration.
This preclinical study demonstrates the feasibility of manipulating ferromagnetic fine particles in the vascular system using magnetic fields, with potential applications in imaging and targeted therapy.
Nakamura et al. (1971) studied this question. Carbonyl iron ferromagnetic fine particles (FFP) was evaluated on Behavior of FFP in the vascular system and conditions for aggregation/dispersion. Carbonyl iron ferromagnetic fine particles introduced into the vascular system require suitable coating, spherical shape, and superposed magnetic fields to aggregate and disperse in small vessels.
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