Key result
Short-term pretreatment with captopril maintained renal plasma flow and glomerular filtration rate without compromising blood pressure control compared to placebo during open heart surgery.
Why the study?
Does short-term pretreatment with captopril preserve blood pressure and renal function in patients without pre-existing cardiac or renal failure undergoing coronary artery bypass?
RCT (n=18)
Double-blind
Does short-term pretreatment with captopril preserve blood pressure and renal function in patients without pre-existing cardiac or renal failure undergoing coronary artery bypass?
Short-term pretreatment with captopril preserves renal function without compromising blood pressure control during coronary artery bypass surgery.
Supports short-term captopril pretreatment before CABG to protect renal function; extends perioperative ACEI evidence to low-risk patients without baseline failure.
Activation of the renin-angiotensin system during open heart surgery may have consequences both beneficial in sustaining blood pressure and deleterious in compromising renal hemodynamics. The influence of short-term pretreatment with captopril on blood pressure and renal function was assessed double-blind versus placebo in 18 patients without pre-existing cardiac or renal failure, and undergoing coronary artery bypass. No difference in blood pressure and fluid requirement during the surgical period was observed between groups receiving captopril or placebo. Effective renal plasma flow and glomerular filtration rate decreased in the placebo group whereas they remained unaltered in the captopril group; during cardiopulmonary bypass, urinary excretion of sodium was greater in patients receiving captopril than those receiving placebo. These results suggest that captopril pretreatment does not compromise the control of blood pressure and renal function during open heart surgery; additional studies on the protective value of angiotensin-converting enzyme inhibitors are warranted in patients at higher risk for developing renal failure.
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Colson et al. (1990) conducted an RCT in Coronary artery bypass surgery (n=18). Captopril vs. Placebo was evaluated on Blood pressure and renal function. Short-term pretreatment with captopril maintained renal plasma flow and glomerular filtration rate without compromising blood pressure control compared to placebo during open heart surgery.
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