Influence of Intravenous Administration of Angiotensin-Converting Enzyme Inhibitor Enalaprilat on Cardiovascular Mediators in Cardiac Surgery Patients

28 patients undergoing aortocoronary bypass grafting with a mean arterial blood pressure (MAP) > 85 mm Hg after induction of anesthesia.

Enalaprilat 0.06 mg/kg intravenous (IV)

Saline solution as placebo

Cardiovascular mediators (Endothelin, atrial natriuretic peptide, epinephrine, norepinephrine, ACE activity) and hemodynamics (MAP, heart rate, cardiac index, systemic vascular resistance) measured at baseline, 10 min, 30 min, before CPB, after CPB, and at the end of surgerysurrogate