Why the study?
Does intravenous enalaprilat reduce intraoperative hemodynamic and hormonal responses in patients undergoing limb procedures with general anesthesia and a pneumatic tourniquet?
Population
30 patients undergoing limb procedures with general anesthesia and a pneumatic tourniquet
Comparison
Preoperative enalaprilat or intraoperative… vs Appropriate placebo controls
Design
RCT, randomized, placebo-controlled
Follow-up
intraoperative
Authors
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IV enalaprilat does not blunt tourniquet hypertension; challenges renin-angiotensin mediation of the response.
Does intravenous enalaprilat reduce intraoperative hemodynamic and hormonal responses in patients undergoing limb procedures with general anesthesia and a pneumatic tourniquet?
Intravenous enalaprilat does not reduce tourniquet-induced hypertension during limb surgery, suggesting the response is mediated by pain pathways rather than the renin-angiotensin system.
Heropoulos et al. (1995) studied this question.
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