Why the study?
Does intravenous enalaprilat prevent perioperative hypertensive reactions in chronically treated hypertensive patients undergoing CABG?
Population
38 male patients chronically treated for arterial hypertension and scheduled for coronary artery bypass…
Comparison
Intravenous enalaprilat 30 micrograms/kg… vs Intravenous NaCl 0.9% administered at the time…
Design
RCT, randomly, double-blindly
Follow-up
Up to 2 hours after admission to the intensive care unit
Authors
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Prophylactic IV enalaprilat does not reduce rescue needs in hypertensive CABG patients; challenges its routine use and directs research to alternatives.
Does intravenous enalaprilat prevent perioperative hypertensive reactions in chronically treated hypertensive patients undergoing CABG?
Prophylactic administration of intravenous enalaprilat at skin incision does not prevent hypertensive reactions or reduce the need for rescue antihypertensives during CABG in chronically hypertensive patients.
Schuetz et al. (1998) studied this question.
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