Why the study?
Does intravenous enalaprilat reduce hemodynamic and hormonal responses during surgery in patients undergoing limb procedures with general anesthesia?
Population
30 patients undergoing limb procedures with general anesthesia and a pneumatic tourniquet
Comparison
Preoperative enalaprilat or intraoperative… vs Appropriate placebo controls
Design
RCT, randomized, placebo-controlled
Follow-up
intraoperative
Authors
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Enalaprilat should not be used to blunt tourniquet hypertension; challenges angiotensin mediation and supports pain pathway involvement.
Does intravenous enalaprilat reduce hemodynamic and hormonal responses during surgery in patients undergoing limb procedures with general anesthesia?
Prophylactic or intraoperative intravenous enalaprilat does not reduce tourniquet-induced hypertension during limb surgery, indicating the response is likely mediated by pain pathways.
Heropoulos et al. (1995) studied this question.
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