Key result
Altered thyroid status in rats did not significantly change the maximal contractile responses of abdominal aorta vascular rings to endothelin-1 compared to euthyroid controls.
Population
40 rats (14 hypothyroid, 14 hyperthyroid, 12 euthyroid)
Comparison
Propylthiouracil to induce hypothyroidism or… vs Euthyroid rats
Design
Preclinical
Follow-up
approximately 3 months
Authors
Loading...
Thyroid status unlikely to affect ET-1 contraction in rat conduit arteries; leaves open relevance to human vessels or resistance beds.
p-value: p=NS
Altered thyroid status does not significantly affect endothelium-dependent vasoconstriction to endothelin-1 in rat conduit arteries.
McAllister et al. (2000) studied Altered thyroid status (n=40). Altered thyroid status (hypothyroidism or hyperthyroidism) vs. Euthyroid rats was evaluated on Maximal contractile responses to endothelin-1 (p=NS). Altered thyroid status in rats did not significantly change the maximal contractile responses of abdominal aorta vascular rings to endothelin-1 compared to euthyroid controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: