Key result
Nutritional factors regulate the tissue availability and biological actions of IGFs by altering specific binding proteins, such as decreasing GHBP and IGFBP-3 during severe malnutrition.
Nutritional status plays a key role in regulating growth hormone and insulin-like growth factor-binding proteins, which may impact tissue availability and biological actions of IGFs.
Nutritional status may inform IGF axis interpretation in malnourished patients; leaves open whether binding-protein modulation improves outcomes in trials.
Both growth hormone (GH) and insulin-like growth factors (IGFs) associate with specific binding proteins. Besides control by hormones, these binding proteins are nutritionally regulated. The GH-binding protein (GHBP) is the extracellular portion of the GH receptor. Its concentrations in circulation are decreased in severe malnutrition, reflecting a decrease in tissue GH receptor abundance. IGFs are bound to 6 different binding proteins (IGFBPs). IGFBP-3 is relatively stable and is only depressed after prolonged periods of severe malnutrition. In contrast, IGFBP-1 is regulated acutely by nutrient intake, showing major elevations after overnight fasting and rapid postprandial decreases. IGFBP-2 is highly dependent on dietary protein intake. Nutritional factors may regulate the tissue availability and the biological actions of IGFs by their actions on IGFBPs.
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Ketelslegers et al. (2008) conducted a review in Malnutrition / Nutritional regulation. Nutritional factors (nutrient intake, fasting, malnutrition) was evaluated. Nutritional factors regulate the tissue availability and biological actions of IGFs by altering specific binding proteins, such as decreasing GHBP and IGFBP-3 during severe malnutrition.
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