Key result
In 25-OH-D3-deficient dialysis patients, 8 weeks of oral vitamin D supplementation significantly improved endothelial dysfunction, increasing percent flow-mediated dilatation from 5.4 to 10.25 (P<0.001).
Why the study?
Does oral vitamin D supplementation improve endothelial dysfunction in 25-OH-D3-deficient hemodialysis patients?
Population
29 uremic patients on dialysis and 20 healthy controls
Comparison
Oral vitamin D 50,000 units for 8 weeks vs Pre-treatment baseline and healthy controls
Design
Cohort
Follow-up
8 weeks
Authors
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May improve endothelial function in deficient dialysis patients; hypothesis-generating and requires randomized confirmation before practice change.
Does oral vitamin D supplementation improve endothelial dysfunction in 25-OH-D3-deficient hemodialysis patients?
Absolute Event Rate: 10.25% vs 5.4%
p-value: p=< 0.001
Vitamin D supplementation for 8 weeks significantly improves endothelial function (measured by %FMD) in 25-OH-D3-deficient hemodialysis patients.
Karakaş et al. (2016) studied Chronic kidney disease on hemodialysis (n=49). Vitamin D (cholecalciferol) vs. Before supplementation was evaluated on percent flow-mediated dilatation (%FMD) (p=< 0.001). In 25-OH-D3-deficient dialysis patients, 8 weeks of oral vitamin D supplementation significantly improved endothelial dysfunction, increasing percent flow-mediated dilatation from 5.4 to 10.25 (P<0.001).
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