VIRULENCE OF DIPHTHERIA-LIKE ORGANISMS,[TMTz BALT I39 than in the male.Acute degeneration of the whole -gland fonowed inoculation with the non-lipoid cortical constituents, together with adrenaline.Thyroid.-The gland was apparently stimulated by the cortex, but adrenaline over-stimulated it to the point of exhaustion.Haemrolyrnph Glands.-Themost striking change observed was in tho pigment.Three types could be distinguished.First, the yellow-brown amorphous pigment due to break- down of haemoglobin; this was always increased, showing that the suprarenal stimulates blood destruction.Secondly, bright yellow pigment in fatty droplets, probablv representing some of the inoculated lipoid material laid down in altered form in tlhese glanis.Tlhirdly, brown pigment found in special cells of.varying size and shape in varying amounts; these are melanoblast cells, and were found most frequently in the haemolymplh glands, occasionally in the truLe lymph glands, and rarely in almost any situation, distributed by the lymph channels.The suggestive point about these cells is that they were only found when the preparation contained adrenaline, and never under any other conditions.Excessive or perverted activity of the suprarenal medulla, therefore, may be directly responsible for the pigment formation of Addison's disease and may also play a part in the formation of pigmented tumours.Conclusiovs.Altlhough it is not possible to apply-results obtained witlh certain animals to another species, nor possible always to distinguish .betweenglandularlhyperactivity and perverted activity, nor between purely structural lhyperplasia and functional hyperplasia, yet the following conclusions seem wortly-of -record:1.The suprare'nal cortex plays a part in fat metabolism and in calcium metabolism.. The suprarenal cortex stimulates the thymus to
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Eagleton et al. (1922) studied this question.