What question did this study set out to answer?

To identify the specific nucleotide sequences and molecular basis of HLA class II DR3 and DR4 associations with autoimmune hepatitis susceptibility.

March 1, 1994Hepatology

Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis†

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Authors

DDDerek G. DohertyTrinity College PDPeter T. DonaldsonKing's College School JUJames A. UnderhillKing's College Hospital NHS Foundation Trust

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Implication

Case-control study uncovers specific HLA class II alleles linked to autoimmune hepatitis, indicating that distinct genotypes define separate clinical courses.

Key Points

To identify the specific nucleotide sequences and molecular basis of HLA class II DR3 and DR4 associations with autoimmune hepatitis susceptibility.
Assessed hypervariable nucleotide sequences of DRB, DQA, and DQB using oligonucleotide probes in 119 white patients with autoimmune hepatitis and 177 matched controls.
DRB3*0101 was present in 58% of patients versus 25% of controls (corrected P < 0.000005), and DRB1*0401 was enriched in DRB3*0101-negative patients, with either allele appearing in 81% of patients versus 42% of controls (corrected P < 0.0000001).
A conserved hexapeptide motif (Leu-Leu-Glu-Gln-Lys-Arg) at positions 67–72 of the DR beta chain was found in 94% of patients compared to 64% of controls (corrected P < 0.000001) and in all patients positive for anti-asialoglycoprotein receptor autoantibodies.
Patients possessing DRB1*0401 experienced milder illness, relapsed less frequently, and presented significantly later in life than those possessing DRB3*0101.

Cite This Study

Doherty et al. (1994) studied this question.

synapsesocial.com/papers/6a97d45948723bb28e366e22 https://doi.org/10.1002/hep.1840190311

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Implication

Case-control study uncovers specific HLA class II alleles linked to autoimmune hepatitis, indicating that distinct genotypes define separate clinical courses.

Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis†

Discussion

Member takes

Implication

Key Points

Cite This Study

Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis†

Discussion

Member takes

Implication

Key Points

Cite This Study

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