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In vitro study reveals antiproliferative activity of Camellia sinensis tea polysaccharides against HeLa cervical cancer cells, suggesting potential therapeutic applications in oncology.
Tea polysaccharides (TPS) were analyzed and characterized by HPAEC, GPC, FT-IR, AFM, HSQC, and HMBC NMR as well as methylation. The TPS mainly consisted of neutral (F0, F0.2, and F0.3) and acidic polysaccharides (F0.1) rich in glucuronic acid. Moreover, anti-proliferative activity of the TPS on HeLa cells was investigated. It was found that F0 exhibited the highest inhibition rate (36.7%) with 200 µg/ml treatment for 48 h. Structural characterization revealed that F0 had a backbone chain of (1→4)-β-d-Glcp, (1→6)-α-d-Galp, (1→2)-α-l-Rhap and (1→2,4)-α-l-Rhap residues with (1→6)-α-d-Galp and acetyl group side chains.
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Gao et al. (2021) studied this question.
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