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Polyribosomes were isolated from reovirus-infected L-cells. Virus-induced RNA isolated from these polyribosomes was single-stranded, heterogeneous in size, and capable of extensive hybridization with viral double-stranded RNA. Reovirus RNA, therefore, specifies in infected cells the formation of a single-stranded messenger RNA for virus-specific protein synthesis.
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Prevec et al. (1966) studied this question.
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