Key result
A genome-wide linkage scan identified a novel genetic locus for plasma triglyceride levels on chromosome 1p31-32 (peak multipoint LOD = 3.12) in families with premature CAD and MI.
Observational (n=714)
Effect estimate: peak multipoint LOD 3.12
Identified a novel genetic locus on chromosome 1p31-32 associated with plasma triglyceride levels in families with premature CAD and MI.
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No immediate clinical implications for lipid management; leaves open replication and functional validation of this triglyceride locus in CAD families.
Seidelmann et al. (2008) conducted an observational in Premature CAD and MI (n=714). Genetic locus on chromosome 1p31-32 was evaluated on Linkage for the quantitative triglyceride trait (peak multipoint LOD 3.12). A genome-wide linkage scan identified a novel genetic locus for plasma triglyceride levels on chromosome 1p31-32 (peak multipoint LOD = 3.12) in families with premature CAD and MI.
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