Key result
Decreased heart rate variability, defined as a fractal dimension ≤ 1.05, was significantly associated with an increased risk of poststroke depression at 3 months (adjusted OR 3.31).
Why the study?
Stroke causes cardiac autonomic dysfunction, and depression and cognitive impairment are common complications after AIS, but their relationship with heart rate variability was unclear.
Observational (n=476)
Single-blind
No
May flag poststroke depression risk; hypothesis-generating and should not yet change practice.
Background Stroke has been shown to cause cardiac autonomic dysfunction. Depression and cognitive impairment are common complications after acute ischemic stroke (AIS). The relationship between poststroke depression (PSD) and cognitive impairment (PCI) and heart rate variability(HRV) was unclear.
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Wang et al. (2019) conducted an observational in Acute mild-moderate ischemic stroke (n=476). Decreased heart rate variability (Fractal dimension ≤ 1.05) vs. Normal heart rate variability (Fractal dimension > 1.05) was evaluated on Poststroke depression (PSD) at 3 months (adjusted OR 3.31, 95% CI 1.81-5.43, p=0.000). Decreased heart rate variability, defined as a fractal dimension ≤ 1.05, was significantly associated with an increased risk of poststroke depression at 3 months (adjusted OR 3.31).
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