What is the clinical evidence from this study?

Study design: Review. Population: Essential hypertension.

What question did this study set out to answer?

To evaluate whether essential hypertension represents a single uniform clinical entity or comprises distinct pathogenetic subgroups, with an emphasis on endocrine and adrenal mechanisms.

March 1, 1954Annals of Internal Medicine

Studies on "Essential" Hypertension. V. An Endocrine Hypertensive Syndrome

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Key result

Essential hypertension is proposed to be a syndrome caused by several pathogenetic mechanisms rather than a single disease, with four distinct types of arterial hypertension delineated.

Population

Patients with so-called "essential" hypertension

Design

Review

Authors

HSHenry A. SchroederDartmouth College DDDean F. DaviesColumbia University

Discussion

Member takes

Implication

Challenges monolithic view of essential hypertension; leaves open whether four subtypes improve stratification or therapy selection.

Key Points

To evaluate whether essential hypertension represents a single uniform clinical entity or comprises distinct pathogenetic subgroups, with an emphasis on endocrine and adrenal mechanisms.
Conducted detailed clinical examinations and diagnostic evaluations on hospitalized individuals presenting with arterial hypertension.
Categorized patient manifestations across distinct subtypes, differentiating renal parenchymal disease from diencephalic and endocrine-related hypertensive phenotypes.
Identified essential hypertension as a heterogeneous syndrome driven by multiple distinct etiologic pathways rather than a solitary disease process.
Characterized a distinct endocrine hypertensive syndrome linked to adrenal cortical hyperfunction that presents with distinguishable clinical and metabolic features.

Structured PICO

Population

Patients with so-called "essential" hypertension

This historical paper proposes that essential hypertension is not a single disease but a syndrome comprising multiple distinct pathogenetic mechanisms.

Cite This Study

Schroeder et al. (1954) conducted a review in Essential hypertension. Essential hypertension is proposed to be a syndrome caused by several pathogenetic mechanisms rather than a single disease, with four distinct types of arterial hypertension delineated.

synapsesocial.com/papers/6a97d8956ac1408ff2e17107 https://doi.org/10.7326/0003-4819-40-3-516

Topics

Hypertension management

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Studies on "Essential" Hypertension. V. An Endocrine Hypertensive Syndrome

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Studies on "Essential" Hypertension. V. An Endocrine Hypertensive Syndrome

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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