Absolute Event Rate: 72% vs 45%
Hypercholesterolemia in a guinea pig model leads to cardiovascular dysfunction characterized by increased AT1 receptor expression, enhanced eicosanoid formation, and suppressed NO production.
Preclinical guinea pig data warrant no clinical changes; leaves open mechanistic relevance to human cardiovascular disease.
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Schwemmer et al. (2000) studied Hypercholesterolemia. 1% cholesterol diet vs. Normal diet was evaluated on AT1 receptor expression (fmol/mg protein).
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