Key result
Among adults newly initiating antihypertensive therapy, ACE inhibitors were the most common first-line class (39%), followed by beta-blockers (31%) and calcium channel blockers (24%).
Why the study?
Knowledge of real-world antihypertensive use was limited to prevalent hypertension, limiting understanding of treatment evolution and its contribution to poor blood pressure control.
What are the real-world patterns of initial antihypertensive prescribing among new users?
Observational (n=143,054)
Yes
What are the real-world patterns of initial antihypertensive prescribing among new users?
There is substantial variation in initial antihypertensive prescribing in real-world practice, including high rates of β-blocker initiation, indicating significant gaps between current guideline recommendations and clinical implementation.
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Observed variation in initial antihypertensive choices signals implementation gaps; leaves open barriers to guideline adherence and need for targeted research.
Smith et al. (2022) conducted an observational in Hypertension (n=143,054). First-line antihypertensives was evaluated on Initial antihypertensive regimen by class and drug. Among adults newly initiating antihypertensive therapy, ACE inhibitors were the most common first-line class (39%), followed by beta-blockers (31%) and calcium channel blockers (24%).
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