Key result
SEN virus infection prevalence was not significantly different between patients with unexplained hepatitis and control subjects when controlling for geographic region.
Why the study?
Is SEN virus infection associated with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis?
Case-Control (n=1,706)
Yes
Is SEN virus infection associated with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis?
p-value: p=not significant
SEN virus does not appear to have an etiological role in cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or non-A-E hepatitis.
No support for SEN virus testing in unexplained hepatitis; observational data leave other etiologies open for cryptogenic liver failure.
SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated.
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Umemura et al. (2003) conducted a case-control in Cryptogenic Acute Liver Failure, Hepatitis-Associated Aplastic Anemia, or Acute and Chronic Non-A-E Hepatitis (n=1,706). SEN virus (SENV) infection vs. Control subjects with liver disease and healthy control subjects was evaluated on Prevalence of SENV (p=not significant). SEN virus infection prevalence was not significantly different between patients with unexplained hepatitis and control subjects when controlling for geographic region.
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