What question did this study set out to answer?

To evaluate the effects of 12-week astaxanthin supplementation on glucose metabolism, insulin sensitivity, and lipid profiles in healthy individuals and subjects with prediabetes.

December 7, 2021NutrientsOpen Access

The Beneficial Effects of Astaxanthin on Glucose Metabolism and Modified Low-Density Lipoprotein in Healthy Volunteers and Subjects with Prediabetes

View Full Paper

Ask AI

Bookmark

Authors

MUMasaharu UrakazeKamiichi General Hospital CKChikaaki KobashiKamiichi General Hospital YSYukihiro Satou

Discussion

Member takes

Implication

Randomized placebo-controlled trial reveals astaxanthin improves glucose control and reduces modified low-density lipoprotein in prediabetes, suggesting preventive efficacy against diabetes.

Key Points

To evaluate the effects of 12-week astaxanthin supplementation on glucose metabolism, insulin sensitivity, and lipid profiles in healthy individuals and subjects with prediabetes.
Conducted a randomized, placebo-controlled trial involving 53 subjects administered either 12 mg astaxanthin or a placebo once daily for 12 weeks.
Assessed HbA1c, lipid profiles, 75 g oral glucose tolerance test (OGTT) response, Matsuda index of insulin resistance, vascular endothelial function, and visceral fat area.
Astaxanthin significantly decreased 120-minute glucose levels during a 75 g OGTT, reduced HbA1c from 5.64 ± 0.33% to 5.57 ± 0.39% (p < 0.05), and improved the Matsuda index.
Circulating apo E decreased from 4.43 ± 1.29 to 4.13 ± 1.24 mg/dL (p < 0.05) and malondialdehyde-modified low-density lipoprotein decreased from 87.3 ± 28.6 to 76.3 ± 24.6 U/L (p < 0.05), with no changes in total cholesterol, triglycerides, or HDL-C.

Cite This Study

Urakaze et al. (2021) studied this question.

synapsesocial.com/papers/6a97dad82855ae6cf374d495 https://doi.org/10.3390/nu13124381

View Full Paper

Ask AI

Bookmark

Implication

Randomized placebo-controlled trial reveals astaxanthin improves glucose control and reduces modified low-density lipoprotein in prediabetes, suggesting preventive efficacy against diabetes.

The Beneficial Effects of Astaxanthin on Glucose Metabolism and Modified Low-Density Lipoprotein in Healthy Volunteers and Subjects with Prediabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

The Beneficial Effects of Astaxanthin on Glucose Metabolism and Modified Low-Density Lipoprotein in Healthy Volunteers and Subjects with Prediabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider