Key result
Angiopoietin-2 overexpression in a rat glioma model led to an 86% decrease in tumor growth and increased median survival to 34 days compared to 20 days in controls.
Population
Syngenic male Fischer 344 rats weighing between 200 and 250 g with an intracerebral 9L glioma model.
Comparison
Implantation of 9L glioma cells stably… vs Implantation of 9L glioma cells transfected with…
Design
Preclinical
Follow-up
Until death (median survival up to 34 days)
Authors
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Hypothesis-generating for Ang2 modulation in glioma; should not yet change clinical practice pending human data.
Effect estimate: 70% increase
Absolute Event Rate: 34% vs 20%
p-value: p=<0.001
In a rat glioma model, Ang2 overexpression delays tumor growth and prolongs survival by altering tumor vessel morphology and decreasing permeability, leading to inadequate tumor oxygenation.
Valable et al. (2009) studied Glioblastoma (brain tumor model) (n=45). Angiopoietin-2 (Ang2) overexpression vs. 9L-control (empty vector) was evaluated on Median survival (70% increase, p=<0.001). Angiopoietin-2 overexpression in a rat glioma model led to an 86% decrease in tumor growth and increased median survival to 34 days compared to 20 days in controls.
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