Why the study?
Does ectopic expression of Ang-2 compromise the survival benefit and vessel normalization of anti-VEGFR2 treatment in mice bearing gliomas?
Population
Orthotopic glioma model in mice (U87 glioma cells)
Comparison
Ectopic expression of Ang-2 combined with… vs Anti-VEGFR2 treatment alone or control
Design
Preclinical
Authors
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May blunt anti-VEGFR2 benefit in glioma models; hypothesis-generating for dual Ang-2/VEGF blockade, not ready for practice.
Does ectopic expression of Ang-2 compromise the survival benefit and vessel normalization of anti-VEGFR2 treatment in mice bearing gliomas?
In a mouse glioma model, high levels of Ang-2 compromised the survival benefit of anti-VEGFR2 therapy by inhibiting vessel normalization, suggesting a potential role for dual anti-VEGF and anti-Ang-2 therapy.
Chae et al. (2010) studied this question.
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