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March 2, 2010Cancer ResearchOpen Access

Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

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Why the study?

Does combined inhibition of Ang2 and VEGF reduce tumor angiogenesis and growth in a mouse model of colon carcinoma?

Population

Colo205 human colon carcinomas in nude mice

Comparison

Selective inhibition of Ang2 by the peptide-Fc… vs Controls

Design

Preclinical

Follow-up

26 days

Authors

HHHiroya HashizumeHokkaido UniversityBFBeverly L. FalcónEli Lilly (United States)TKTakashi KurodaKagawa University

Discussion

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Implication

Hypothesis-generating in colon carcinoma models; leaves open clinical translation of dual Ang2/VEGF inhibition.

Structured PICO

Does combined inhibition of Ang2 and VEGF reduce tumor angiogenesis and growth in a mouse model of colon carcinoma?

P
Population
Colo205 human colon carcinomas in nude mice
I
Intervention
Selective inhibition of Ang2 by the peptide-Fc fusion protein L1-7(N), alone or combined with a function-blocking anti-VEGF antibody
C
Comparator
Controls
O
Outcome
Tumor growth and number of vascular sprouts over 26 dayssurrogate

Combined inhibition of Ang2 and VEGF synergistically limits tumor vasculature expansion and slows tumor growth in a preclinical colon carcinoma model.

Cite This Study

Hashizume et al. (2010) studied this question.

synapsesocial.com/papers/6a1df5cf871ff5209bef9a05https://doi.org/10.1158/0008-5472.can-09-1977
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