Why the study?
Does Ang1 inhibition, alone or in combination with Ang2 inhibition, suppress angiogenesis and tumor growth in preclinical models?
Population
Preclinical models including normal juvenile rats, hormone-induced ovulation models, tumor xenografts…
Comparison
Angiopoietin-1 inhibition using selective… vs Control, selective Ang2 inhibition, or…
Design
Preclinical
Authors
Loading...
Dual Ang1/2 inhibition merits exploration in angiogenesis models; leaves open clinical translation and patient selection.
Does Ang1 inhibition, alone or in combination with Ang2 inhibition, suppress angiogenesis and tumor growth in preclinical models?
Dual Ang1/2 inhibition is superior to selective Ang2 inhibition for suppressing angiogenesis in specific postnatal settings, highlighting a context-dependent role for Ang1.
Coxon et al. (2010) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: