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July 21, 2011Cancer Research

Ang-2-expressing tumors exhibited diminished pericyte recruitment to blood vessels that were dilated, nonfunctional, and highly permeable, resulting in impaired tumor outgrowth, whereas Ang-1-expressing tumors showed no alteration in tumor outgrowth or vessel maturation; both induced peritumoral lymphangiogenesis.

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Population

Rip1Tag2 transgenic mouse model of pancreatic β-cell carcinogenesis

Comparison

Transgenic expression of human Angiopoietin-1 or… vs Baseline Rip1Tag2 mice without transgenic Ang-1…

Design

Preclinical

Authors

EFErnesta FagianiPLPascal LorentzLKLucie Kopfstein

Discussion

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Overview

Ang-2 vessel effects in mouse tumors should not alter clinical practice; leaves open whether angiopoietin targeting affects human tumor progression or lymphangiogenesis.

Structured PICO

P
Population
Rip1Tag2 transgenic mouse model of pancreatic β-cell carcinogenesis
I
Intervention
Transgenic expression of human Angiopoietin-1 (Ang-1) or Angiopoietin-2 (Ang-2) in pancreatic β cells
C
Comparator
Baseline Rip1Tag2 mice without transgenic Ang-1 or Ang-2 expression
O
Outcome
Tumor angiogenesis, lymphangiogenesis, and tumor progression (including tumor outgrowth, blood vessel density, vessel maturation, and pericyte recruitment)surrogate

In a mouse model of pancreatic carcinogenesis, Ang-2 antagonizes Ang-1 function to impair vessel stabilization and tumor growth, though both factors independently induce lymphangiogenesis.

Cite This Study

Fagiani et al. (2011) studied this question.

synapsesocial.com/papers/6a87abc6a9eb41bcdfc4db73https://doi.org/10.1158/0008-5472.can-10-4635
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth2009 · 182 citations
  2. 2The Dynamic roles of Angiopoietins in Tumor Angiogenesis2005 · 29 citations
  3. 3Angiopoietin-2 Impairs Revascularization After Limb Ischemia2007 · 113 citations
  4. 4Angiopoietin-1 promotes lymphatic sprouting and hyperplasia2005 · 236 citations
  5. 5Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin‐22008 · 53 citations