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June 1, 2007Circulation ResearchOpen Access

Restoration of blood flow in Ang-2:Tie1 transgenic mice is dramatically impaired when Ang-2 expression is induced, evidenced by reduced collateral artery growth, reduced movement capacities, and higher incidents of necrosis compared with controls.

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Why the study?

Does induced Angiopoietin-2 expression impair revascularization after limb ischemia in mice?

Population

Transgenic mouse model with targeted Ang-2 expression in endothelial cells subjected to arterial artery…

Comparison

Induction of Angiopoietin-2 expression in the… vs Control mice

Design

Preclinical

Authors

YRYvonne ReissGoethe University FrankfurtJDJasmin DrosteGoethe University FrankfurtMHMatthias HeilUniversity of Manchester

Discussion

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Overview

Ang-2 induction impairs revascularization in murine limb ischemia; leaves open its role in human peripheral artery disease.

Structured PICO

Does induced Angiopoietin-2 expression impair revascularization after limb ischemia in mice?

P
Population
Transgenic mouse model with targeted Ang-2 expression in endothelial cells (Ang-2:Tie1 transgenic mice) subjected to arterial artery occlusion in the limb
I
Intervention
Induction of Angiopoietin-2 (Ang-2) expression in the vasculature
C
Comparator
Control mice
O
Outcome
Restoration of blood flow/perfusion after arterial occlusionsurrogate

Angiopoietin-2 expression in endothelial cells impairs revascularization and collateral artery growth after limb ischemia in mice, suggesting precise Ang-2 dosage is required for blood vessel growth.

Cite This Study

Reiss et al. (2007) studied this question.

synapsesocial.com/papers/6a7148ad3ce530166bc30e49https://doi.org/10.1161/circresaha.106.143594
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia2016 · 8 citations
  2. 2Angiopoietin-2 Stimulates Blood Flow Recovery After Femoral Artery Occlusion by Inducing Inflammation and Arteriogenesis2008 · 62 citations
  3. 3Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage2013 · 179 citations
  4. 4Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth2009 · 182 citations
  5. 5Early Vessel Destabilization Mediated by Angiopoietin-2 and Subsequent Vessel Maturation via Angiopoietin-1 Induce Functional Neovasculature after Ischemia2013 · 45 citations