October 9, 2009American Journal Of PathologyOpen Access

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

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Population

Mice with human Colo205 tumors

Design

Preclinical

Authors

BFBeverly L. FalcónEli Lilly (United States)HHHiroya HashizumeHokkaido University PKPetros KoumoutsakosHarvard University

Discussion

Member takes

Implication

Supports mechanistic research on Ang2 in tumor vascular remodeling; leaves open clinical translation pending human evidence.

Structured PICO

Population

Mice with human Colo205 tumors

Intervention

Selective inhibitors of Ang1 (mL4-3) or Ang2 (L1-7[N]), alone or in combination

Outcome

Tumor blood vessel normalization and tumor vascularitysurrogate

Inhibition of Ang2 normalizes tumor blood vessels by permitting unopposed Ang1 action, providing mechanistic insights into tumor angiogenesis and vascular remodeling.

Cite This Study

Falcón et al. (2009) studied this question.

synapsesocial.com/papers/6a7d3196ab1caed3bf7496ac https://doi.org/10.2353/ajpath.2009.090391

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Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider