Key result
Alfentanil (1.2 mg/kg) and sufentanil (13.1 µg/kg) anesthesia prevented changes in plasma levels of ADH and GH and maintained cardiovascular dynamics during coronary artery bypass surgery.
Why the study?
Does alfentanil or sufentanil anesthesia prevent changes in antidiuretic hormone and growth hormone levels in patients undergoing coronary artery bypass surgery?
Population
29 patients undergoing coronary artery bypass surgery
Design
Cohort
Follow-up
End of surgery
Authors
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May guide opioid selection in CABG anesthesia; leaves open randomized confirmation of hemodynamic or outcome benefits.
Does alfentanil or sufentanil anesthesia prevent changes in antidiuretic hormone and growth hormone levels in patients undergoing coronary artery bypass surgery?
Alfentanil and sufentanil anesthesia prevent significant changes in ADH and GH levels during coronary artery bypass surgery, potentially blocking hormonal stress responses better than fentanyl.
Lange et al. (1982) studied Coronary artery bypass surgery (n=29). Alfentanil-oxygen and sufentanil-oxygen anesthesia vs. Historical controls (fentanyl) was evaluated on Antidiuretic hormone (ADH), growth hormone (GH), and cardiovascular responses. Alfentanil (1.2 mg/kg) and sufentanil (13.1 µg/kg) anesthesia prevented changes in plasma levels of ADH and GH and maintained cardiovascular dynamics during coronary artery bypass surgery.