Key result
Two elderly patients developed severe cardiac conduction disturbances requiring permanent pacemaker implantation shortly after receiving their first dose of a COVID-19 vaccine.
Why the study?
Although COVID-19 vaccines have been linked to rare cardiovascular effects like myopericarditis, cardiac conduction disease in this context has only rarely been reported.
Case Report (n=2)
This report highlights a rare potential safety signal of severe cardiac conduction disturbance requiring permanent pacemaker implantation following COVID-19 vaccination.
Rare myopericarditis signals after COVID-19 vaccination warrant vigilance; leaves open causality and risk-benefit questions for prospective study.
Since the end of 2020, several vaccines have become available as part of the global efforts to contain the adverse health outcomes of the coronavirus disease 2019 (COVID-19) pandemic. Although research has confirmed their safety on large scales, several post-marketing reports have revealed some rare cardiovascular side effects. Towards the end of the first half of 2021, multiple reports indicate possible links between COVID-19 vaccines (both mRNA-based vaccine and vector-based vaccines) and myopericarditis. Nevertheless, cardiac conduction disease in this context has only rarely been reported. In this report, we present two cases of probable vaccination-induced cardiac conduction disturbances along with a thorough literature review. In addition, we discuss probable pathophysiological mechanisms and insights into the suggested areas for future research. To our knowledge, these are the first published cases to result in permanent pacemaker implantation.
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Elhassan et al. (2021) conducted a case report in Cardiac conduction disturbance (n=2). COVID-19 vaccination was evaluated on Development of severe cardiac conduction disturbance requiring permanent pacemaker implantation. Two elderly patients developed severe cardiac conduction disturbances requiring permanent pacemaker implantation shortly after receiving their first dose of a COVID-19 vaccine.
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