Key result
In numerical simulations, a preload-based Starling-like controller outperformed pulsatility control and constant speed operation by increasing mean pump flow by 54% during exercise and maintaining a greater safety margin against left ventricular suction during hemorrhage.
Why the study?
Does a preload-based Starling-like controller improve hemodynamic responses to physiological stressors compared to pulsatility control and constant speed operation in a numerical model of implantable rotary blood pumps?
Population
Validated mathematical model of the human circulation and the VentrAssist left ventricular assist device
Comparison
Preload-based Starling-like controller using… vs Pulsatility controller and constant speed…
Design
Preclinical
Authors
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Preload-based Starling-like control performs in LVEDP simulations; leaves open clinical translation and prospective human validation.
Does a preload-based Starling-like controller improve hemodynamic responses to physiological stressors compared to pulsatility control and constant speed operation in a numerical model of implantable rotary blood pumps?
In a numerical simulation, a preload-based Starling-like controller for rotary blood pumps provided superior hemodynamic support during exercise, hemorrhage, and reduced LV contractility compared to pulsatility control and constant speed operation.
Mansouri et al. (2015) studied Heart failure requiring implantable rotary blood pumps (IRBPs). Preload-based Starling-like controller vs. Pulsatility control and constant speed operation was evaluated on Mean pump flow and left ventricular end-diastolic pressure during physiological transitions. In numerical simulations, a preload-based Starling-like controller outperformed pulsatility control and constant speed operation by increasing mean pump flow by 54% during exercise and maintaining a greater safety margin against left ventricular suction during hemorrhage.
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