Key result
LINC-PINT was downregulated in patients with type 2 diabetes who developed cardiomyopathy and retinopathy, suggesting its overexpression may inhibit the progression of these complications.
Why the study?
The role of LncRNA LINC-PINT in diabetes and its related complications had not yet been determined.
Observational (n=370)
No
Downregulation of LncRNA LINC-PINT is associated with the progression of cardiomyopathy and retinopathy in patients with type 2 diabetes.
LINC-PINT downregulation may flag T2D complication risk; hypothesis-generating and requires prospective validation before any clinical use.
BACKGROUND Despite the acknowledgement that LncRNA LINC-PINT may inhibit tumor cell invasion in human cancers, it is not yet determined when it comes to diabetes and its related complications. MATERIAL AND METHODS There were 244 patients with T2D and 126 healthy volunteers were admitted to People's Hospital of Xinjiang Uygur Autonomous Region Hospital. Fasting blood (5 mL) was obtained from the patients and controls a day after admission. The diabetes patients' fasting blood was extracted once every 6 months during follow-up. The total RNA was extracted and then used for detecting the expression of LINC-PINT. RESULTS A comparison was made in this study, where LINC-PINT did not experience significant downregulation level in the majority of those suffering diabetes complications when in contrast to healthy controls, while LINC-PINT expression was found in diabetics. The follow-up study showed that LINC-PINT was downregulated in patients who developed cardiomyopathy and retinopathy or both but not in patients who developed other complications. Treatment with high glucose limited the extent of LINC-PINT expression in the ARPE-19 and AC16 cells. While the overexpression of LINC-PINT increased the viability of ARPE-19 and AC16 cells, siRNA-mediated silencing of LINC-PINT elicited the opposite effect. CONCLUSIONS Hence, we concluded that the overexpression of LINC-PINT may exhibit inhibitory effects on the progression of cardiomyopathy and retinopathy among patients with type 2 diabetes.
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Zha et al. (2019) conducted an observational in Type 2 Diabetes (n=370). LncRNA LINC-PINT expression vs. Healthy volunteers and patients without cardiomyopathy or retinopathy was evaluated on Development of cardiomyopathy and retinopathy. LINC-PINT was downregulated in patients with type 2 diabetes who developed cardiomyopathy and retinopathy, suggesting its overexpression may inhibit the progression of these complications.
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