Synthetic methodology study demonstrates the production of β- and γ-carbolinones in indole-derived precursors, highlighting an atom-efficient route under mild conditions.
A novel protocol for Fe(III)‐mediated 6‐ endo‐ trig radical cyclization of indole‐based Ugi 4‐CR adducts has been developed, facilitating the synthesis of β ‐ and γ ‐carbolinones via the formation of Fe(III)–H as a key species. This atom‐efficient approach proceeds under mild conditions and demonstrates broad functional group tolerance.
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Olvera‐Granados et al. (2026) studied this question.
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