Successful treatment of coexisting alopecia areata and hidradenitis suppurativa with upadacitinib

Q: What does this research mean for the field?

Upadacitinib can successfully treat coexisting alopecia areata and hidradenitis suppurativa. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Patrícia Moreira Gomes; Rúben Costa; Ana Pedrosa; Cármen Lisboa

doi:10.1016/j.abd.2026.501453

August 31, 2026Anais Brasileiros de DermatologiaOpen Access

Successful treatment of coexisting alopecia areata and hidradenitis suppurativa with upadacitinib

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Key Points

To document the therapeutic response to the selective Janus kinase inhibitor upadacitinib in a patient with concurrent, refractory alopecia areata and hidradenitis suppurativa.
Clinical case evaluation of a 24-year-old woman with Down syndrome, hypothyroidism, and concurrent refractory alopecia areata and hidradenitis suppurativa (N=1).
Assessment of disease history following multiple failed treatments, including systemic antibiotics, surgical excision, topical immunotherapies, and corticosteroids.
Upadacitinib therapy achieved successful clinical improvement in both chronic inflammatory skin conditions.
Dual response indicates that selective JAK-STAT pathway inhibition effectively dampens the dysregulated innate and adaptive immune cascades driving both follicular disorders.

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Implication

Case report demonstrates successful management of coexisting alopecia areata and hidradenitis suppurativa with upadacitinib, suggesting shared therapeutic utility of JAK inhibition.

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Gomes et al. (2026) studied this question.

synapsesocial.com/papers/6a97e28dc562ede874ec6ba3 https://doi.org/10.1016/j.abd.2026.501453

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Successful treatment of coexisting alopecia areata and hidradenitis suppurativa with upadacitinib

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Successful treatment of coexisting alopecia areata and hidradenitis suppurativa with upadacitinib

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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