Retrospective cohort study observes cognitive function alongside atherogenic indices in Alzheimer’s disease, highlighting vascular contributions to cognitive decline.
Key Points
To evaluate the relationship between circulating lipid parameters, including the atherogenic index of plasma, and cognitive performance measured concurrently and after two years in Alzheimer's disease.
Retrospective cohort design reviewing N=84 patients with Alzheimer's disease followed at a university dementia outpatient clinic between 2016 and 2025.
Measured fasting lipid panels (total cholesterol, LDL, HDL, triglycerides) and calculated lipid ratios alongside the atherogenic index of plasma (log[TG/HDL]).
Assessed cognitive performance using the Mini-Mental State Examination (MMSE) at baseline (N=84) and at a two-year follow-up visit (N=41).
Cross-sectional correlation analyses examined relationships between atherogenic index of plasma values, standard lipid fractions, and baseline MMSE scores.
Longitudinal assessments evaluated the predictive relevance of baseline lipid profiles on changes in MMSE performance across the two-year follow-up period.