Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 2, 2026HLAOpen Access

Identification of the Novel HLA‐A*02:04:03 Allele by Long‐Read Sequencing Following a Short‐Read Phasing Failure

View Full Paper
Ask AI
Bookmark
Share

Authors

MNMaja NørgaardPKPernille Koefoed‐Nielsen

Discussion

Loading...

Member takes

Overview

Genomic analysis reveals a novel HLA-A*02:04:03 allele resolved exclusively by long-read sequencing, highlighting key resolution limits in short-read phasing.

Key Points

  • Characterize a suspected novel HLA-A allele that could not be successfully resolved using standard short-read sequencing phasing methods.
  • Analyzed genomic DNA using both long-read sequencing and short-read sequencing platforms to resolve ambiguous allele phasing.
  • Identified and phased the novel human leukocyte antigen allele HLA-A*02:04:03 using long-read sequencing.
  • Short-read sequencing failed to phase the target region and missed detection of the novel variant.

Cite This Study

Nørgaard et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2b1c562ede874ec6eb7https://doi.org/10.1111/tan.70961
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of the Novel <i>HLA‐A*02:540:02N</i> Allele by Next‐Generation Sequencing2025
  2. 2The Novel <i>HLA‐A*03:531</i> Allele Identified by Next‐Generation Sequencing in Related Donor Screening2026
  3. 3Identification of the Novel <i>HLA‐A*02:1269</i> Allele by Next‐Generation Sequencing2026 · 1 citations
  4. 4Identification of a Novel <scp>HLA</scp> ‐A Allele, <i>HLA‐A*02:02:09</i> , Discovered by Next‐Generation Sequencing2026 · 1 citations
  5. 5The Novel <i>HLA‐A*02:1139</i> Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual2026 · 1 citations