What does this research mean for the field?

Water-soluble copper(II) and manganese(III) phthalocyanines (CuPc and MnPc) exhibit potent in vitro α-glucosidase inhibitory activity, demonstrating significantly lower IC50 values than the standard drug acarbose. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the alpha-glucosidase inhibitory activity and binding characteristics of two water-soluble metallophthalocyanines, CuPc and MnPc, as potential antidiabetic agents.

September 2, 2026Cumhuriyet Science JournalOpen Access

In vitro and in silico α-glucosidase Inhibition Studies of Two Water-soluble Copper(II) and Manganese(III) Phthalocyanines

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Authors

MÇMustafa Çeşme MAMelike Yıldırım Akatın ZBZekeriya Bıyıklıoğlu

Discussion

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Overview

In vitro and in silico analysis demonstrates alpha-glucosidase inhibition by copper and manganese phthalocyanines, suggesting potential antidiabetic therapeutic value.

Key Points

To evaluate the alpha-glucosidase inhibitory activity and binding characteristics of two water-soluble metallophthalocyanines, CuPc and MnPc, as potential antidiabetic agents.
In vitro enzyme inhibition assays and enzyme kinetic evaluations comparing CuPc and MnPc to the standard drug acarbose.
In silico molecular docking simulations targeting alpha-glucosidase (PDB ID: 3WY2) to characterize binding affinity and interaction profiles.
CuPc and MnPc exhibited IC50 values of 14.90 ± 0.59 µM and 12.91 ± 0.29 µM, respectively, compared to 237.24 ± 1.80 µM for acarbose.
MnPc acted as a competitive inhibitor with a Ki value of 1.88 µM.
Molecular docking revealed binding affinities of -9.8 kcal/mol for CuPc and -9.3 kcal/mol for MnPc against alpha-glucosidase.

Cite This Study

Çeşme et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2b1c562ede874ec6f00 https://doi.org/10.17776/csj.1834754

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September 2, 2026Cumhuriyet Science JournalOpen Access

In vitro and in silico α-glucosidase Inhibition Studies of Two Water-soluble Copper(II) and Manganese(III) Phthalocyanines

View Full Paper

Ask AI

Bookmark

Authors

MÇMustafa Çeşme MAMelike Yıldırım Akatın ZBZekeriya Bıyıklıoğlu

Discussion

Member takes

Overview

In vitro and in silico analysis demonstrates alpha-glucosidase inhibition by copper and manganese phthalocyanines, suggesting potential antidiabetic therapeutic value.

Key Points

To evaluate the alpha-glucosidase inhibitory activity and binding characteristics of two water-soluble metallophthalocyanines, CuPc and MnPc, as potential antidiabetic agents.
In vitro enzyme inhibition assays and enzyme kinetic evaluations comparing CuPc and MnPc to the standard drug acarbose.
In silico molecular docking simulations targeting alpha-glucosidase (PDB ID: 3WY2) to characterize binding affinity and interaction profiles.
CuPc and MnPc exhibited IC50 values of 14.90 ± 0.59 µM and 12.91 ± 0.29 µM, respectively, compared to 237.24 ± 1.80 µM for acarbose.
MnPc acted as a competitive inhibitor with a Ki value of 1.88 µM.
Molecular docking revealed binding affinities of -9.8 kcal/mol for CuPc and -9.3 kcal/mol for MnPc against alpha-glucosidase.

Cite This Study

Çeşme et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2b1c562ede874ec6f00 https://doi.org/10.17776/csj.1834754

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