What does this research mean for the field?

Anti-Ro52 antibody positivity in patients with primary Sjögren's disease is independently associated with a significantly higher frequency of interstitial lung disease and a distinct serological profile. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association of anti-Ro52 antibody positivity with interstitial lung disease, clinical manifestations, and serological features in primary Sjögren’s disease.

September 2, 2026Clinical and Experimental MedicineOpen Access

Association of anti-Ro52 antibody positivity with interstitial lung disease and serological features in primary Sjögren’s disease

View Full Paper

Ask AI

Bookmark

To evaluate the association of anti-Ro52 antibody positivity with interstitial lung disease, clinical manifestations, and serological features in primary Sjögren’s disease.
Retrospective cross-sectional study analyzing 205 patients with primary Sjögren’s disease classified by anti-Ro52 status (101 positive, 104 negative).
Multivariable binary logistic regression assessed the independent link between anti-Ro52 and interstitial lung disease, with Benjamini-Hochberg false discovery rate adjustments for exploratory comparisons.
Interstitial lung disease occurred more frequently in anti-Ro52-positive than anti-Ro52-negative patients (27.7% vs. 10.6%, p = 0.003).
Anti-Ro52 positivity independently predicted interstitial lung disease after adjusting for age, sex, smoking, and disease duration (adjusted OR 3.61, 95% CI 1.64–7.96, p = 0.001), and after further adjustment for anti-SSA positivity (adjusted OR 4.48, 95% CI 1.86–10.81, p < 0.001).
Anti-Ro52-positive patients exhibited significantly higher frequencies of anti-SSA, anti-SSB, and a speckled antinuclear antibody pattern following false discovery rate correction.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Retrospective cross-sectional study reveals elevated interstitial lung disease risk in anti-Ro52-positive primary Sjögren’s disease, highlighting its value in clinical phenotyping.

Cite This Study

Kaya et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2b1c562ede874ec6f4e https://doi.org/10.1007/s10238-026-02276-3

View Full Paper

Ask AI

Bookmark

Implication

Retrospective cross-sectional study reveals elevated interstitial lung disease risk in anti-Ro52-positive primary Sjögren’s disease, highlighting its value in clinical phenotyping.

Association of anti-Ro52 antibody positivity with interstitial lung disease and serological features in primary Sjögren’s disease

Key Points

Discussion

Implication

Cite This Study

Association of anti-Ro52 antibody positivity with interstitial lung disease and serological features in primary Sjögren’s disease

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider