Long term trends in Cardiac Arrest associated Mortality With Co-Listed Ischemic Heart Disease Among U.S. Adults ≥65 Years, 1999-2024

This population based retrospective study examined long-term trends in cardiac arrest associated mortality with co listed ischemic heart disease among U.S. adults aged ≥65 years from 1999 through 2024 using CDC WONDER Multiple Cause of Death data. Mortality trends were evaluated using age-adjusted mortality rates, annual percent changes (APC), and average annual percent change (AAPC) with Joinpoint regression. An ARIMA model was used to project mortality through 2030. A total of 1,050,867 deaths were identified. Overall mortality remained relatively stable across the study period (AAPC +0.07%), with a marked increase from 2018–2021 (APC +9.93%) followed by a decline from 2021–2024 (APC −7.30%). Men had higher age-adjusted mortality rates than women throughout the study period. The ARIMA model projected an age-adjusted mortality rate of 98.8 per 100,000 by 2030 (95% prediction interval, 80.9–116.8). These findings demonstrate stable long-term mortality with a pronounced pandemic-era increase followed by an incomplete recovery, highlighting the continued burden of cardiac arrest–associated mortality among older U.S. adults with co-listed ischemic heart disease.