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September 2, 2026Journal of Craniofacial Surgery

Hemorrhage in Adult Moyamoya Disease With Intracranial Aneurysms: A Long-Term Observational Study on the Roles of Moyamoya Vessels and Admission Glasgow Coma Scales

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Authors

MFMajing FengYZYonghe ZhengJHJunwen Hu

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Overview

Cohort study identifies ipsilateral moyamoya vessels and low admission Glasgow Coma Scale as predictors of hemorrhage in adult moyamoya disease, highlighting key targets for long-term clinical...

Key Points

  • Identify independent risk factors for intracranial hemorrhage and evaluate hemorrhage-free survival in adult patients diagnosed with moyamoya disease and associated intracranial aneurysms.
  • Retrospective single-center cohort study evaluating 69 consecutive adult patients with moyamoya disease and intracranial aneurysms enrolled between March 2014 and October 2021.
  • Tracked outcomes across treatments—including conservative care, endovascular intervention, surgical clipping, and revascularization—over a median follow-up of 76.2 months, confirming hemorrhage via computed tomography.
  • Over the follow-up period, 17 of 69 patients (24.6%) developed intracranial hemorrhage, while 52 of 69 (75.4%) maintained hemorrhage-free survival.
  • Logistic regression identified ipsilateral moyamoya vessels harboring aneurysms (P = 0.018) and low admission Glasgow Coma Scale scores (P < 0.001) as independent predictors of hemorrhage.
  • Cox regression confirmed that both aneurysm-bearing ipsilateral moyamoya vessels (P = 0.003) and lower admission Glasgow Coma Scale scores (P < 0.001) significantly reduced hemorrhage-free survival, while age, sex, and perfusion deficits showed no significant association.

Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/6a97e2eac562ede874ec7455https://doi.org/10.1097/scs.0000000000013308
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Moyamoya Disease Presenting as a Transient Ischemic Attack Following Recurrent Intracerebral and Intraventricular Hemorrhage2026
  2. 2Clinical features, treatment and long-term outcomes of hemorrhagic moyamoya disease in children: an extensive follow-up study2025
  3. 3Distinct Clinical Phenotypes in Moyamoya Disease: A Multicenter Comparison of Ischemic and Hemorrhagic Presentations2026
  4. 4Computed Tomography Angiography Recognition of a Hemorrhagic Moyamoya Pattern May Alter Acute Blood Pressure Management2026
  5. 5Pediatric Hemorrhagic Moyamoya Disease2026 · 2 citations