What does this research mean for the field?

Body mass index is independently associated with incident treated hypertension and provides modest additional prognostic value beyond age, with the relative effect of obesity being strongest in early midlife. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association between baseline body mass index category and incident treated hypertension and determine whether body mass index improves risk prediction beyond standard predictors in adult men.

September 2, 2026Chronic Diseases and Translational MedicineOpen Access

Baseline obesity in men is linked to ~88% greater 10-year risk of treated hypertension.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Hypertension (n=12742). Intervention: Obesity (Body Mass Index Category) vs. Normal weight. Primary outcome: incident treated hypertension (HR 1.88, 95% CI 1.59-2.22).

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Why the study?

Excess adiposity is a major modifiable risk factor for hypertension, but the incremental prognostic value of BMI beyond standard predictors remains unclear.

Does baseline BMI category predict incident treated hypertension in adult men?

Population

12,742 men aged ≥ 18 years without treated hypertension at baseline

Comparison

Baseline BMI categories (underweight, overweight, obese vs normal weight)

Design

Linked prospective cohort study

Follow-up

133,038 person-years

Key result

Baseline obesity in men was associated with an increased 10-year cumulative incidence of treated hypertension compared to normal weight (20.5% vs 7.5%; HR 1.88, 95% CI 1.59-2.22).

Authors

EAEbenezer Afrifa‐Yamoah

Discussion

Member takes

Overview

Supports BMI in hypertension risk stratification for men; extends observational data with age-specific effects and modest discrimination gains.

Key Points

To evaluate the association between baseline body mass index category and incident treated hypertension and determine whether body mass index improves risk prediction beyond standard predictors in adult men.
Analyzed prospective cohort data from the Ten to Men study (2013–2024) linked with Australian Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) records.
Followed 12,742 men aged ≥ 18 years without treated hypertension at baseline for 133,038 person-years using multivariable-adjusted Cox proportional hazards models and bootstrap validation.
Antihypertensive therapy was initiated in 1,755 men (13.2 per 1,000 person-years), with 10-year cumulative incidence rising from 7.5% (95% CI 6.6–8.3) in normal-weight men to 20.5% (95% CI 18.9–22.0) in obese men.
Fully adjusted hazard ratios versus normal weight were 1.43 (95% CI 1.16–1.77) for underweight, 1.42 (95% CI 1.22–1.67) for overweight, and 1.88 (95% CI 1.59–2.22) for obesity.
A significant age interaction (p < 0.01) showed stronger obesity effects at ages 30–44 years (HR 2.39, 95% CI 1.91–2.98) than at ages ≥ 45 years (HR 1.57, 95% CI 1.28–1.94), with BMI addition improving overall discrimination to C = 0.754.

Study Design

Type

Cohort (n=12,742)

Structured PICO

Does baseline BMI category predict incident treated hypertension in adult men?

Population

12,742 Australian men aged ≥ 18 years without treated hypertension at baseline, followed for 133,038 person-years.

Exposure

Baseline BMI category (underweight, overweight, obese)

Comparator

Normal-weight men

Outcome

Incident treated hypertensionhard clinical

Main Result

Hazard Ratio: 1.88 (95% CI 1.59–2.22)

Absolute Event Rate: 20.5% vs 7.5%

Baseline BMI is independently associated with incident treated hypertension in men, with obesity having the strongest relative effect in early midlife.

Cite This Study

Ebenezer Afrifa‐Yamoah (2026) conducted a cohort in Hypertension (n=12,742). Obesity (Body Mass Index Category) vs. Normal weight was evaluated on incident treated hypertension (HR 1.88, 95% CI 1.59-2.22). Baseline obesity in men was associated with an increased 10-year cumulative incidence of treated hypertension compared to normal weight (20.5% vs 7.5%; HR 1.88, 95% CI 1.59-2.22).

synapsesocial.com/papers/6a97e2f6c562ede874ec7637 https://doi.org/10.1002/cdt3.70064

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September 2, 2026Chronic Diseases and Translational MedicineOpen Access

Baseline obesity in men is linked to ~88% greater 10-year risk of treated hypertension.

View Full Paper

Ask AI

Bookmark

Why the study?

Excess adiposity is a major modifiable risk factor for hypertension, but the incremental prognostic value of BMI beyond standard predictors remains unclear.

Does baseline BMI category predict incident treated hypertension in adult men?

Population

12,742 men aged ≥ 18 years without treated hypertension at baseline

Comparison

Baseline BMI categories (underweight, overweight, obese vs normal weight)

Design

Linked prospective cohort study

Follow-up

133,038 person-years

Key result

Baseline obesity in men was associated with an increased 10-year cumulative incidence of treated hypertension compared to normal weight (20.5% vs 7.5%; HR 1.88, 95% CI 1.59-2.22).

Authors

EAEbenezer Afrifa‐Yamoah

Discussion

Member takes

Overview

Supports BMI in hypertension risk stratification for men; extends observational data with age-specific effects and modest discrimination gains.

Key Points

To evaluate the association between baseline body mass index category and incident treated hypertension and determine whether body mass index improves risk prediction beyond standard predictors in adult men.
Analyzed prospective cohort data from the Ten to Men study (2013–2024) linked with Australian Pharmaceutical Benefits Scheme (PBS) and Medicare Benefits Schedule (MBS) records.
Followed 12,742 men aged ≥ 18 years without treated hypertension at baseline for 133,038 person-years using multivariable-adjusted Cox proportional hazards models and bootstrap validation.
Antihypertensive therapy was initiated in 1,755 men (13.2 per 1,000 person-years), with 10-year cumulative incidence rising from 7.5% (95% CI 6.6–8.3) in normal-weight men to 20.5% (95% CI 18.9–22.0) in obese men.
Fully adjusted hazard ratios versus normal weight were 1.43 (95% CI 1.16–1.77) for underweight, 1.42 (95% CI 1.22–1.67) for overweight, and 1.88 (95% CI 1.59–2.22) for obesity.
A significant age interaction (p < 0.01) showed stronger obesity effects at ages 30–44 years (HR 2.39, 95% CI 1.91–2.98) than at ages ≥ 45 years (HR 1.57, 95% CI 1.28–1.94), with BMI addition improving overall discrimination to C = 0.754.

Study Design

Type

Cohort (n=12,742)

Structured PICO

Does baseline BMI category predict incident treated hypertension in adult men?

Population

12,742 Australian men aged ≥ 18 years without treated hypertension at baseline, followed for 133,038 person-years.

Exposure

Baseline BMI category (underweight, overweight, obese)

Comparator

Normal-weight men

Outcome

Incident treated hypertensionhard clinical

Main Result

Hazard Ratio: 1.88 (95% CI 1.59–2.22)

Absolute Event Rate: 20.5% vs 7.5%

Baseline BMI is independently associated with incident treated hypertension in men, with obesity having the strongest relative effect in early midlife.

Cite This Study

synapsesocial.com/papers/6a97e2f6c562ede874ec7637 https://doi.org/10.1002/cdt3.70064

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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