Key result
A baseline BMI ≥25.0 was associated with a higher risk of incident hypertension compared to a BMI <19.0, with hazard ratios ranging from 1.29 to 1.47 across age and sex groups.
Why the study?
Does baseline BMI ≥ 25.0 increase the risk of incident hypertension compared to BMI < 19.0 in nonhypertensive Japanese adults?
Cohort (n=68,205)
Does baseline BMI ≥ 25.0 increase the risk of incident hypertension compared to BMI < 19.0 in nonhypertensive Japanese adults?
Baseline BMI ≥ 25.0 is significantly associated with an increased risk of incident hypertension in Japanese adults, independent of weight change during follow-up.
Answers are grounded in this paper and cite their sources.
May inform risk assessment in nonhypertensive Japanese adults; leaves open whether weight loss prevents incident hypertension.
OBJECTIVE: The aim of this study was to examine the association between BMI and risk of incident hypertension among Japanese men and women who are middle-aged and older. DESIGN: Prospective, population-based cohort study. PATIENTS: A total of 68 205 nonhypertensive adults (18 336 men and 49 869 women) aged 40-79 years who completed health check-ups in the Ibaraki prefecture, Japan, in 1993 were followed up through 2006. To exclude the impact of BMI change during the follow-up period, a time-dependent covariate Cox proportional hazards model was used to compute the hazard ratios of incident hypertension according to BMI categories. Incident hypertension was defined as a SBP of at least 140 mmHg, a diastolic BP of at least 90 mmHg, and/or hypertensive medication use. RESULTS: A total of 30 982 adults (45.4%) developed hypertension (9331 men and 21 651 women) during a mean of 3.9 years of follow-up. Compared with a BMI of less than 19.0, time-dependent covariates adjusted hazard ratios [95% confidence interval (CI)] for hypertension among participants with a BMI of at least 25.0 were 1.42 (1.17-1.73) for men aged 40-59 years, 1.34 (1.19-1.51) for men aged 60-79 years, 1.47 (1.33-1.62) for women aged 40-59 years, and 1.29 (1.18-1.41) for women aged 60-79 years. CONCLUSION: The baseline BMI is associated with future risk for incident hypertension even after accounting for weight change during the follow-up period. Weight loss may be recommended to nonhypertensive obese adults to prevent the development of hypertension.
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Tsujimoto et al. (2012) conducted a cohort in Nonhypertensive (n=68,205). BMI ≥25.0 vs. BMI <19.0 was evaluated on Incident hypertension (SBP ≥140 mmHg, DBP ≥90 mmHg, and/or hypertensive medication use) (HR 1.42, 95% CI 1.17-1.73). A baseline BMI ≥25.0 was associated with a higher risk of incident hypertension compared to a BMI <19.0, with hazard ratios ranging from 1.29 to 1.47 across age and sex groups.
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