Chemical study demonstrates base-promoted cascade synthesis of aza-bicyclic maleimides and spiro-oxindoles from aminomaleimides, indicating a versatile route to complex heterocycles.
A base‐promoted aza‐Michael/S N 2′ and Michael‐Nucleophilic addition sequential reaction enables efficient preparations of aza‐bicyclic maleimides and tricyclic spiro‐oxindoles in generally good yields (up to 99% yield) with excellent diastereoselectivities (up to 20:1 dr) from α‐aminomaleimides and electron‐deficient olefins.
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Liu et al. (2026) studied this question.
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