Key result
Ultrasonic attenuation and backscatter were significantly increased in regions of infarction compared to nonischemic regions (P<0.001) and correlated closely with regional collagen content.
Population
18 dogs studied 2, 4, and 6 weeks after coronary occlusion and 21 rabbits studied 5 to 7 weeks after…
Comparison
Measurement of ultrasonic attenuation and… vs Nonischemic regions from the same hearts
Design
Preclinical
Follow-up
2 to 7 weeks post-occlusion
Authors
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May support ultrasonic fibrosis estimation postinfarction; leaves open clinical translation and validation.
p-value: p=<0.001
Ultrasonic backscatter and attenuation are strongly influenced by myocardial collagen content, suggesting reflected ultrasound could noninvasively estimate myocardial fibrosis.
Mimbs et al. (1980) studied Myocardial infarction (n=39). Coronary occlusion and collagenase perfusion vs. Nonischemic regions was evaluated on Ultrasonic attenuation, backscatter, and collagen content (p=<0.001). Ultrasonic attenuation and backscatter were significantly increased in regions of infarction compared to nonischemic regions (P<0.001) and correlated closely with regional collagen content.
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