The adsorption of drugs on silica aerogels has been investigated. Adsorption takes place from the solution of a corresponding drug in supercritical CO 2 . Adsorption isotherms were measured for one model substance, naphthalene, and two drugs, ketoprofen and miconazole, at 40 °C. It has been shown that both drugs exhibit a high affinity to silica aerogel, what gives a possibility to use aerogels as a drug carrier in aerogel-drug formulations. The knowledge of the adsorption isotherm allows to control the loading of aerogels with drugs in such formulations. Both hydrophilic and hydrophobic aerogels can be used as a carrier. The influence of the hydrophobicity of the carrier material on the adsorption process is discussed.
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Смирнова et al. (2003) studied this question.
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