Answers are grounded in this paper and cite their sources.
The solubility of racemic paroxetine intermediate in supercritical carbon dioxide was measured in the pressure range from (9 to 24) MPa and at temperatures of (308.2, 318.2, and 328.2) K using a continuous flow-type apparatus equipped with a high-pressure UV−Vis detector. Results showed that under the present operation conditions, the experimentally determined solubility of the racemic compound was in the range of (7.3 × 10 -5 to 1.2 × 10 -3 ) in mole fraction. The solubility increased with rising pressure at constant temperature, and the crossover pressure was found to locate at around 12 MPa for the three solubility isotherms. An empirical density-based Chrastil's equation was used to fit the experimental solubility data, giving a good correlation with an AARD of 7.56 %.
No takes yet. Share an insight, caveat, or question.
Bao et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: